. 2017 Oct 9;69(11):1714–1723. doi: 10.1002/acr.23165

Table 2.

Mean comorbidities, no. medications, and scores for depression, anxiety, and quality of life by dryness sensitivity classification. Proportions of patients in the different groups with specific comorbidities and receiving particular treatments^a

	Ocular sensitivity					Oral sensitivity
	Stoical (n = 351)	Accurate (n = 130)	Sensitive (n = 200)	Comparison	P	Stoical (n = 444)	Accurate (n = 179)	Sensitive (n = 58)	Comparison	P
No. comorbidities	3.4 ± 2.3	3.9 ± 2.5	3.8 ± 2.6	F_2,678 = 2.90	0.056	3.4 ± 2.3	3.8 ± 2.6	3.9 ± 2.7	F_2,678 = 9.5	0.078
No. medications	5.5 ± 4.1	5.7 ± 3.7	6.3 ± 4.2	F_2,678 = 2.52	0.081	5.4 ± 3.9^b	6.6 ± 4.5^c	5.8 ± 3.9^d	F_2,678 = 4.97^e	0.007^e
Anxiety (HADS)	7.3 ± 4.5^b	8.4 ± 4.8^c	8.9 ± 4.4^c	F_2,661 = 8.75^e	< 0.001^e	7.3 ± 4.4^b	9.0 ± 4.8^c	10.2 ± 4.0^c	F_2,661 = 16.45^e	< 0.001^e
Depression (HADS)	5.3 ± 3.7^b	6.4 ± 4.3^c	6.9 ± 4.3^c	F_2,661 = 11.23^e	< 0.001^e	5.2 ± 3.6^b	7.2 ± 4.4^c	8.1 ± 4.3^c	F_2,661 = 24.00^e	< 0.001^e
Quality of life (VAS)	63.8 ± 20.6^b	56.6 ± 22.5^c	56.3 ± 21.2^c	F_2,659 = 10.09^e	< 0.001^e	63.4 ± 20.2^b	54.3 ± 22.5^c	53.9 ± 22.7^c	F_2,659 = 14.14^e	< 0.001^e
Specific comorbidities
Fibromyalgia	6.3^c	8.5^d	14.0^b	Χ²(2) = 9.39^e	0.009^e	7.0^c	11.2^d	17.2^b	Χ²(2) = 8.08^e	0.018^e
IBS	5.4^c	7.7^d	12.0^b	Χ²(2) = 7.70^e	0.021^e	7.7^c	5.0^c	17.2^b	Χ²(2) = 9.13^e	0.010^e
Mental illness	3.1	6.2	4.0	Χ²(2) = 2.27	0.321	2.7	6.7	5.2	Χ²(2) = 5.61	0.061
Treatments, %
Xerogenic medication use	37.3^b	46.2^d	50.0^c	Χ²(2) = 9.14^e	0.010^e	39.2	48.6	51.7	Χ²(2) = 6.72^e	0.035^e
Symptomatic treatment for dryness	97.7	96.9	97.5	Χ²(2) = 0.25	0.883	97.1	97.8	100.0	Χ²(2) = 1.875	0.392
Pilocarpine	7.1	9.2	7.5	Χ²(2) = 0.61	0.739	7.2	10.1	3.4	Χ²(2) = 3.04	0.218
Saliva substitute	–	–	–	–		40.1^b	56.4^c	43.1^d	Χ²(2) = 13.83^e	0.001^e
Lachrymal substitute	82.6^c	83.1^c	71.5^b	Χ²(2) = 10.95^e	0.004^e	–	–	–	–
Punctal plugging or cauterization	18.8^b	33.8^c	22.0^d	Χ²(2) = 12.33^e	0.002^e	–	–	–	–

Values are the mean ± SD unless otherwise indicated. HADS = Hospital Anxiety and Depression Scale; VAS = visual analog scale; IBS = irritable bowel syndrome.

Significantly different from groups ‡ and § in post hoc tests (P < 0.05 for continuous measures, P < 0.017 for categorical measures).

Significantly different from groups † and § in post hoc tests (P < 0.05 for continuous measures, P < 0.017 for categorical measures).

Significantly different from groups † and ‡ in post hoc tests (P < 0.05 for continuous measures, P < 0.017 for categorical measures).

Statistically significant.