TABLE 1.
Genetic associations of SNPs in the SLC2A14 gene to UC and CD1
| Controls, n = 142 | UC, n = 149 | UC vs. control, OR (95% CI) | CD, n = 162 | CD vs. control, OR (95% CI) | |
| rs12815313 | |||||
| CC | 73 (51.4) | 59 (39.6) | Ref | 54 (33.4) | Ref |
| CT | 55 (38.7) | 71 (47.6) | 1.59 (0.98, 2.61) | 83 (51.2) | 2.04 (1.25, 3.33)* |
| TT | 14 (9.9) | 19 (12.7) | 1.68 (0.78, 3.63) | 25 (15.4) | 2.41 (1.15, 5.07)* |
| T carrier | 69 (48.59) | 90 (60.4) | 1.61 (1.01, 2.57)* | 108 (66.7) | 2.12 (1.33, 3.36)* |
| rs10845990 | |||||
| TT | 34 (23.9) | 29 (19.5) | Ref | 32 (19.7) | Ref |
| GT | 68 (47.9) | 64 (42.9) | 1.10 (0.60, 2.01) | 76 (46.9) | 1.19 (0.66, 2.13) |
| GG | 40 (28.2) | 56 (37.6) | 1.64 (0.86, 3.11) | 54 (33.4) | 1.43 (0.76, 2.70) |
| G carrier | 108 (76.1) | 120 (80.5) | 1.30 (0.74, 2.28) | 130 (80.25) | 1.28 (0.74, 2.21) |
| rs11612319 | |||||
| GG | 66 (46.5) | 65 (43.6) | Ref | 79 (48.8) | Ref |
| GA | 66 (46.5) | 69 (46.3) | 1.06 (0.66, 1.72) | 65 (40.1) | 0.82 (0.51, 1.32) |
| AA | 10 (7.0) | 15 (10.1) | 1.52 (0.64, 3.64) | 18 (11.1) | 1.50 (0.65, 3.48) |
| A carrier | 79 (53.5) | 84 (56.4) | 1.12 (0.71, 1.78) | 83 (51.2) | 0.91 (0.58, 1.43) |
| rs7132415 | |||||
| GG | 37 (26.1) | 36 (24.2) | Ref | 31 (19.1) | Ref |
| GT | 70 (49.3) | 76 (51.0) | 1.12 (0.64, 1.96) | 72 (44.5) | 1.23 (0.69, 2.19) |
| TT | 35 (24.6) | 37 (24.8) | 1.09 (0.57, 2.08) | 59 (36.4) | 2.01 (1.07, 3.79) |
| T carrier | 105 (73.9) | 113 (75.8) | 1.11 (0.65, 1.88) | 131 (80.9) | 1.49 (0.87, 2.56) |
| rs10846086 | |||||
| AA | 128 (90.1) | 113 (75.8) | Ref | 122 (75.4) | Ref |
| AG | 9 (6.3) | 17 (11.4) | 2.14 (0.92, 4.99) | 20 (12.3) | 2.33 (1.02, 5.32)* |
| GG | 5 (3.5) | 19 (12.8) | 4.30 (1.56, 11.9)* | 20 (12.3) | 4.20 (1.53, 11.5)* |
| G carrier | 14 (9.9) | 36 (24.2) | 2.91 (1.49, 5.68)* | 40 (24.7) | 3.00 (1.55, 5.78)* |
| rs2376904 | |||||
| GG | 93 (65.5) | 83 (55.7) | Ref | 113 (69.8) | Ref |
| GA | 43 (30.3) | 58 (38.9) | 1.51 (0.92, 2.47) | 37 (22.8) | 0.70 (0.42, 1.19) |
| AA | 6 (4.2) | 8 (5.4) | 1.49 (0.50, 4.48) | 12 (7.4) | 1.65 (0.59, 4.55) |
| A carrier | 49 (34.5) | 66 (44.3) | 1.51 (0.94, 2.42) | 49 (30.2) | 0.82 (0.51, 1.33) |
| rs7300773 | |||||
| TT | 50 (35.2) | 47 (31.5) | Ref | 57 (35.2) | Ref |
| CT | 74 (52.1) | 74 (49.7) | 1.06 (0.64, 1.78) | 76 (46.9) | 0.90 (0.54, 1.48) |
| CC | 18 (12.7) | 28 (18.8) | 1.65 (0.81, 3.37) | 29 (17.9) | 1.41 (0.70, 2.85) |
| CT + CC | 92 (64.8) | 102 (68.5) | 1.18 (0.72, 1.92) | 105 (64.8) | 1.00 (0.62, 1.60) |
| rs2889504 | |||||
| GG | 125 (88.0) | 100 (67.1) | Ref | 99 (61.1) | Ref |
| GT | 7 (4.9) | 30 (20.1) | 5.36 (2.26, 12.71)* | 36 (22.2) | 6.49 (2.77, 15.2)* |
| TT | 10 (7.1) | 19 (12.8) | 2.37 (1.06, 5.34)* | 27 (16.7) | 3.41 (1.57, 7.38)* |
| T carrier | 17 (12.0) | 49 (32.9) | 3.60 (1.95, 6.64)* | 63 (38.9) | 4.68 (2.78, 8.50)* |
1
Values are n (%) unless otherwise indicated. Per-allele effects were derived from binary logistic regression performed with SAS version 9.2 (SAS Institute Inc.) through the use of a 3-level genotypic model (2 homozygotes and 1 heterozygote). Overdominance was tested when the heterozygote was not intermediate in effect between the 2 homozygotes. *Significant differences in the ORs to the reference SNPs. CD, Crohn disease; Ref, reference; SLC2, solute carrier family 2; SNP, single nucleotide polymorphism; UC, ulcerative colitis.