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. Author manuscript; available in PMC: 2017 Nov 22.
Published in final edited form as: Handb Exp Pharmacol. 2009;(188):165–196. doi: 10.1007/978-3-540-71029-5_8

Table 4.

Strain-specific responses to three classes of TLR9 ligands (CpGs)

Type A (2336) Type B (1826) Type C (2395)
Mouse strain IFNαa IDOb IFNα IDO IFNα IDO
C57BL6/J ntc − + + + +
CBA nt − + + nt +
BALB/c + − + + − +
129 nt − + − + +
a

IFNα production assessed ex vivo (ELISA) following 5 hrs culture of CD11c+ AMACS enriched DCs with indicated ligand.

b

IDO expression assessed (IHC) 24 hrs treatment in vivo (50-100μg/mouse, i/v).

c

not tested.