Table 2. Optimization of the Perfluoroalkylation.

entry	solvent	base	IRF (equiv)	yielda
1	dioxane	lutidine	2	80%b
2	MeCN	lutidine	2	34%b
3	dioxane	lutidine	2	66%
4	MeCN	lutidine	2	41%b
5	CHCl3	lutidine	2	81%b
6	EtOAc	lutidine	2	88%b
7	EtOAc	lutidine	3	90%
8	EtOAc	lutidine	4	83%
9	EtOAc	lutidine	5	75%
10	EtOAc	KOtBu	3	23%
11	EtOAc	Cs2CO3	3	37%
12	EtOAc	imidazole	3	89%
13	EtOAc	NEt3	3	50%

^aYield determined by ¹⁹F NMR spectroscopy.

^b5 mol % n-Bu₆Sn₂ was used as additive.