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ERK1/2 increases KIM-1 mRNA after toxicant exposure in mouse TKPT cells. (A) KIM-1 mRNA expression after 24 hours following exposure to HU, H2O2, and TBHP. (B) KIM-1 mRNA measured after 24 hours post toxicant administration with or without 1 hour trametinib (GSK) pretreatment. Data are represented as mean ± S.E.M., n ≥ 4. Superscripts indicate statistically significant differences (P < 0.05);*, significantly different than vehicle control; #, significance between same toxicant groups.
