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. 2017 Dec;363(3):419–427. doi: 10.1124/jpet.117.244152

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Fig. 2. — ERK1/2 mediates STAT3 phosphorylation and KIM-1 mRNA upregulation following 3 hours of IR AKI. (A) KIM-1 mRNA expression following IR AKI after 3 hours. (B) Serum creatinine was assessed 3 hours after IR AKI. (C) Representative immunoblot of phosphorylated ERK1/2, total ERK1/2, phosphorylated Chk1, and total Chk1 following 3 hours of IR AKI. (D) Densitometry analysis of phosphorylated ERK1/2 compared with total ERK1/2. (E) Densitometry analysis of phosphorylated Chk1 compared with total Chk1. (F) Representative immunoblot of phosphorylated STAT3 (S727 and Y705) and total STAT3 following 3 hours of IR AKI. (G and H) Densitometry analysis of phosphorylated STAT3 (S727 and Y705) compared with total STAT3. Data are represented as mean ± S.E.M., n = 6. Different superscripts indicate statistically significant differences (P < 0.05).