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. 2017 Dec;363(3):419–427. doi: 10.1124/jpet.117.244152

Fig. 4.

Fig. 4.

ERK1/2 increases KIM-1 mRNA and protein in LPS-induced AKI through TLR4 after 18 hours. (A) Representative immunoblot of KIM-1, phosphorylated ERK1/2, and total ERK1/2 following LPS-induced AKI. (B) Densitometry analysis of phosphorylated ERK1/2 compared with total ERK1/2. (C) TLR4 mRNA measured in WT mice kidney and TLR4KO mice kidney. (D) Representative immunoblot of KIM-1, phosphorylated ERK1/2, and total ERK1/2 following LPS-induced AKI in WT and TLR4KO mice. (E) KIM-1 mRNA measured in the kidneys of WT and TLR4KO mice following LPS-induced AKI after 18 hours. (F) Densitometry analysis of renal phosphorylated ERK1/2 compared with total ERK1/2 in the LPS-treated WT and TLR4KO mice. Data are represented as mean ± S.E.M., n ≥ 3. Different superscripts indicate statistically significant differences (P < 0.05).