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. 2017 Dec;363(3):419–427. doi: 10.1124/jpet.117.244152

Fig. 5.

Fig. 5.

TLR4 is not required for IR-induced ERK1/2 phosphorylation and KIM-1 mRNA upregulation. (A) Representative immunoblot of phosphorylated ERK1/2 and total ERK1/2 following IR-induced AKI after 3 hours in WT and TLR4KO mice. (B) KIM-1 mRNA measured in the kidneys of WT and TLR4KO mice following IR-induced AKI after 3 hours. (C) Densitometry analysis of renal phosphorylated ERK1/2 compared with total ERK1/2 in the WT and TLR4KO mice following IR-induced AKI. Data are represented as mean ± S.E.M., n ≥ 3. Different superscripts indicate statistically significant differences (P < 0.05).