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. 2017 Nov 21;12:183. doi: 10.1186/s13014-017-0923-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow chart of the HEATPAC study protocol. (CT: chemotherapy; RT: radiotherapy; HT: hyperthermia; NACT: neoadjuvant chemotherapy; SIB-IMRT: simultaneous-integrated boost intensity-modulated radiotherapy; IGRT: image guided radiation therapy; GTV: gross target volume; CTV: clinical target volume; FOLFIRINOX: calcium folinate, oxaloplatin, irinotecan, 5-FU)