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Tripartite antagonism of CGRP-induced excitation of spinal neurons. Spinal cord slices were incubated with vehicle (Veh), CGRP8–37, or CGRP8–37–Chol for 60 min; washed; and challenged with CGRP 60 min later. (A) Representative traces. (B) Firing rate normalized to 2 min. (C) Firing duration to last action potential. n = 5–7 neurons per group, n = 21 rats. *P < 0.05. ANOVA, Sidak’s test (firing rate), or Dunn’s test (firing time). ns, not significant.
