Fig. 7.

Tripartite antagonism of nociception. Antagonists were injected intrathecally 3 h before intraplantar injection of capsaicin (Cap, A and B) or formalin (Form, C and D) or 36 h after CFA (E and F). von Frey withdrawal responses to stimulation of the planar surface of the injected paws (A, E, and F) or noninjected paws (B) and nocifensive behavior (C and D) were assessed. Number of mice used in each group is indicated in parentheses. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 to basal or vehicle control. ANOVA, Dunnett’s test.