Fig. 4.

TF binding motifs enriched in the regulatory sequences of 537 DEGs expressed more strongly in CD38⁺ hPGCLCs than in CD38⁻ EB cells. (A) List of significantly enriched TFs (P < 0.01). The P value was defined by the F-match algorithm and calculated by the TRANSFAC server. (B) Locations of the TFAP2 binding motifs in promoters of NANOS3, SOX17, and T/BRACHYURY. Matches to the core motif (GCCNNNGGC) are shown in red, and matches to the additional contributing sequences are shown in orange.