Table 2.
KEGG pathway analysis of differentially expressed miRNAs among the three groups.
| miRNA species | Group with increased expression | Target pathway | Target gens (encoding proteins) |
|---|---|---|---|
| OVX group vs. LIR group | |||
| let-7c-2-3p | OVX | Wnt signaling pathway | LRP6 (LPR6), TCF3 (TCF) |
| miR-322-3p | OVX | Wnt signaling pathway | CREBBP (CBP), FOSL1 (Fra-1) |
| OVX group vs. DM group | |||
| miR-9a-5p | DM | Insulin signaling pathway | RHOQ (RhoQ) |
| Insulin secretion pathway | SLC2A2 (GLUT2), ADCY5 (ADCY5) | ||
| let-7a-1-3p | DM | Wnt signaling pathway | LRP6 (LPR6), TCF3 (TCF) |
| miR-27b-3p | OVX | Osteoclast differentiation pathway | PPARG (PPAR γ) |
| LIR group vs. DM group | |||
| miR-335 | DM | Insulin secretion | ADCY5 (ADCY5) |
| miR-322-3p | DM | Wnt signaling pathway | CREBBP (CBP), FOSL1 (Fra-1) |
KEGG – Kyoto Encyclopedia of Genes and Genomes; OVX – ovariectomized; DM – diabetes mellitus; LIR – liraglutide; LPR6 – lipoprotein receptor-related protein 6; TCF – T cell factor; CBP – Crebbp binding protein; RhoQ – ras homologue family member Q; Fra-1 – FOS-related antigen-1; GLUT2 – glucose transporter type 2; ADCY5 – adenylate cyclase-5; PPAR γ – peroxisome proliferator-activated receptor gamma.