Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Conceptual depiction of the margin of internal exposure (MOIE) approach based on comparison of internal dose metrics. The individual assessment factor (AF) of 4 that should cover interspecies differences in toxicokinetics (TK) can be left out in the MOIE approach as these differences are taking into account using the PBK approach (animal PBK model and human PBK model). aPBK = animal PBK model; hPBK = human PBK model. SED = Systemic exposure dose; SPOD = Systemic Point of Departure.
