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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Stroke. 2017 Apr 17;48(6):1594–1600. doi: 10.1161/STROKEAHA.116.016327

Table 1.

Overview of the Characteristics of Studies Included in the Meta-Analysis

Study Country Design Major Inclusion Criteria Number of Subjects Mean/Median Follow-up (Mo) Outcomes
De Vleeshouwer 200517 Belgium Retrospective cohort Patients with all subtypes of ICH-intraparenchymal, subdural and subarachnoid hemorrhages 108 12 Recurrent ICH; Thromboembolic events; functional outcome
Claassen 200818 United States Retrospective cohort Patients with radiologically documented warfarin-associated intraparenchymal hemorrhage, INR≥1.5, discharge data 48 43 Recurrent ICH; Thromboembolic events
Majeed 201020 Sweden & Canada Retrospective cohort Patients with any warfarin-associated ICH, data from 3 tertiary care hospitals 234 34 Recurrent ICH; Thromboembolic events
Yung 201219 Canada Retrospective cohort Patients with intraparenchymal or subarachnoid hemorrhages, documented warfarin use, excluded trauma/tumors/surgical interventions 284 12 Primary- all-cause mortality, recurrence or expansion of intracranial bleeding. Secondary- composite of death, bleeding or thrombotic complications
Gathier 201312 Netherlands Retrospective cohort Patients with radiologically documented AC-related intraparenchymal hemorrhage, INR≥1.1, discharge data 38 42 Primary- fatal or non-fatal radiologically confirmed cerebral infarction, and recurrent ICH; Secondary- other thrombotic sequelae
Nielsen 201516 Denmark Retrospective cohort Patients with non-valvular atrial fibrillation only, any new incident ICH, AC treatment within 6 months of ICH 1752 12 Recurrent ICH; Thromboembolic events
Kuramatsu 201511 Germany Retrospective cohort Patients with warfarin-associated intraparenchymal hemorrhage, and INR≥1.5 853 12 Primary- Frequency of hematoma enlargement; Secondary-Thromboembolic events, Recurrent ICH, functional outcomes
Ottosen 201615 Denmark Retrospective cohort Patients ≥18 years, with first-time acute spontaneous ICH, and surviving the first 30 days 2978 27.6 All-cause mortality, thromboembolic events, major bleeding, recurrent ICH

Abbreviations: ICH, intracranial hemorrhage; INR, international normalized ratio; Mo, months