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. Author manuscript; available in PMC: 2018 Aug 9.
Published in final edited form as: J Am Chem Soc. 2017 Jul 28;139(31):10597–10600. doi: 10.1021/jacs.7b04726

Figure 4.

Figure 4

Compound 2 inhibits the ATPase activity of TarGH in proteoliposomes but binds in a remote location. (A) Averaged ATPase activity (n=3; error bars=SD) of reconstituted TarGH (200 nM) in the absence (black) and presence (red) of compound 2 (1 µM). Saturating levels of ATP (1 mM) were used. (B) Homology model of TarGH. TarH is cytoplasmic and much of TarG is embedded in the membrane. C) Top view of the TarG dimer. Mutations in residues shown in pink give high level resistance to 2.