Table 4.

Causes of death by degree of HLA-A, -B, -C and –DRB1 mismatch

	HLA match
	Matched	1 allele mismatch	2 allele mismatch	3 allele mismatch	≥4 allele mismatch
Number	46	63	88	105	69
Graft failure	19 (41%)	29 (46%)	42 (48%)	43 (41%)	27 (39%)
Graft versus host disease	1 (2%)	4 (6%)	3 (3%)	11 (10%)	7 (10%)
Interstitial pneumonitis	5 (11%)	3 (5%)	6 (7%)	8 (8%)	4 (6%)
Infection	8 (17%)	4 (6%)	7 (8%)	12 (11%)	10 (14%)
Organ failure	7 (15%)	10 (16%)	14 (16%)	14 (13%)	11 (16%)
Haemorrhage	1 (2%)	3 (5%)	5 (6%)	6 (6%)	2 (3%)
Progressive disease*	2 (4%)	2 (3%)	5 (6%)	3 (3%)	1 (1%)
EBV-PTLD	–	–	2 (2%)	1 (1%)	1 (1%)
Other	2 (4%)	4 (6%)	1 (1%)	2 (2%)	2 (3%)
Not reported	1 (2%)	4 (6%)	3 (3%)	5 (5%)	4 (6%)

Number in parenthesis = column percent

^*Death from progression of primary disease despite donor chimerism ≥95%: Tay-Sachs, Sanfilipo, globoid cell leukodystrophy, metachromatic leukodystrophy and adrenoleukodystrophy

EBV-PTLD = Ebstein-Barr post transplant lymphoproliferative disease