TABLE 2.

Multivariable Association Between Status, Duration of Multivitamin Use and Incidence of Total, Ischemic and Hemorrhagic Stroke

	Total Stroke			Ischemic Stroke			Hemorrhagic Stroke
	Cases	Model 1	Model 2	Cases	Model 1	Model 2	Cases	Model 1	Model 2
Nonusers	925	1.00 (Ref)	1.00 (Ref)	483	1.00 (Ref)	1.00 (Ref)	576	1.00 (Ref)	1.00 (Ref)
Past Users All	731	1.01 (0.91, 1.11)	1.04 (0.93, 1.15)	386	1.04 (0.91, 1.20)	1.01 (0.88, 1.16)	102	0.95 (0.73, 1.23)	1.07 (0.83, 1.40)
< 5 years	331	0.96 (0.84, 1.09)	0.99 (0.87, 1.13)	178	1.00 (0.84, 1.19)	0.97 (0.81, 1.15)	56	1.03 (0.76, 1.41)	1.19 (0.87, 1.64)
≥ 5 years	400	1.05 (0.93, 1.18)	1.08 (0.95, 1.23)	208	1.08 (0.92, 1.28)	1.06 (0.89, 1.26)	46	0.86 (0.61, 1.21)	0.96 (0.68, 1.36)
P for trend		0.24	0.18		0.73	0.77		0.97	0.99
Current users All	1,959	0.93 (0.85, 1.01)	1.02 (0.93, 1.11)	1,020	0.96 (0.85, 1.07)	0.99 (0.88, 1.12)	303	1.03 (0.84, 1.26)	1.21 (0.98, 1.50)
< 5 years	299	0.92 (0.81, 1.05)	0.99 (0.86, 1.13)	169	1.01 (0.84, 1.21)	1.01 (0.85, 1.22)	48	0.85 (0.61, 1.17)	0.98 (0.70, 1.35)
5 – 9 years	410	0.96 (0.85, 1.08)	1.05 (0.93, 1.19)	203	0.92 (0.78, 1.09)	0.95 (0.80, 1.12)	82	1.29 (0.98, 1.70)	1.51 (1.14, 1.99)
10 – 14 years	321	0.84 (0.73, 0.96)	0.91 (0.80, 1.05)	170	0.87 (0.73, 1.04)	0.89 (0.74, 1.06)	58	1.10 (0.80, 1.50)	1.29 (0.94, 1.77)
≥ 15 years	929	0.96 (0.87, 1.06)	1.08 (0.97, 1.20)	478	1.00 (0.87, 1.15)	1.06 (0.91, 1.22)	115	0.95 (0.73, 1.23)	1.13 (0.86, 1.49)
P for trend		0.36	0.12		0.46	0.21		0.87	0.81

Cases=number of stroke events

Model 1 = Adjusted for age and follow-up cycle.

Model 2 = Model 1 + total calories, smoking, BMI, parental history of heart disease, alcohol intake, physical activity, aspirin, post-menopausal therapy use, Alternate Healthy Eating Index, history of hypertension, hypercholesterolemia and diabetes.

P for trend is for linear trend in duration and does not include nonusers.