TABLE 3.

Multivariable Association Between Status, Duration of Multivitamin Use and Stroke Mortality

	Total Stroke			Ischemic Stroke			Hemorrhagic Stroke
	Cases	Model 1	Model 2	Cases	Model 1	Model 2	Cases	Model 1	Model 2
Nonusers	195	1.00 (Ref)	1.00 (Ref)	33	1.00 (Ref)	1.00 (Ref)	90	1.00 (Ref)	1.00 (Ref)
Past Users All	158	0.96 (0.77, 1.20)	1.16 (0.92, 1.45)	40	1.12 (0.69, 1.82)	1.38 (0.83, 2.29)	47	0.81 (0.56, 1.17)	1.03 (0.70, 1.51)
< 5 years	64	0.88 (0.66, 1.18)	1.07 (0.80, 1.44)	16	1.13 (0.61, 2.09)	1.45 (0.76, 2.73)	26	0.91 (0.58, 1.43)	1.19 (0.75, 1.89)
≥ 5 years	94	1.06 (0.81, 1.37)	1.28 (0.98, 1.67)	24	1.15 (0.66, 2.00)	1.41 (0.79, 2.52)	21	0.71 (0.43, 1.17)	0.89 (0.54, 1.48)
P for trend		0.26	0.24		0.44	0.45		0.94	0.88
Current users All	405	0.81 (0.67, 0.97)	1.06 (0.88, 1.29)	99	0.86 (0.56, 1.32)	1.17 (0.74, 1.84)	144	0.86 (0.64, 1.55)	1.15 (0.85, 1.55)
< 5 years	45	0.65 (0.47, 0.90)	0.80 (0.57, 1.12)	9	0.74 (0.35, 1.55)	0.92 (0.43, 1.97)	21	0.67 (0.41, 1.08)	0.87 (0.53, 1.41)
5 – 9 years	86	0.90 (0.69, 1.17)	1.16 (0.89, 1.52)	15	0.69 (0.36, 1.31)	0.94 (0.48, 1.83)	36	1.04 (0.69, 1.55)	1.33 (0.89, 2.01)
10 – 14 years	68	0.79 (0.59, 1.06)	1.03 (0.77, 1.39)	12	0.60 (0.30, 1.20)	0.79 (0.39, 1.61)	32	1.11 (0.72, 1.69)	1.50 (0.97, 2.31)
≥ 15 years	206	0.85 (0.68, 1.06)	1.18 (0.94, 1.48)	63	1.07 (0.67, 1.70)	1.54 (0.94, 2.53)	55	0.76 (0.52, 1.10)	1.05 (0.71, 1.55)
P for trend		0.04	0.01		0.003	0.001		0.92	0.86

Cases=number of stroke events

Model 1 = Adjusted for age and follow-up cycle.

Model 2 = Model 1 + total calories, smoking, BMI, parental history of heart disease, alcohol intake, physical activity, aspirin, post-menopausal therapy use, Alternate Healthy Eating Index, history of hypertension, hypercholesterolemia and diabetes.

P for trend is for linear trend in duration and does not include nonusers.