TABLE 4.
Multivariable Association Between Multivitamin Use and Total Stroke Incidence, Stratified by Key Risk Factors
| Multivitamin User
|
|||||||
|---|---|---|---|---|---|---|---|
| Risk Factors | Cases | Nonuser | Cases | Past User | Cases | Current User | P-interaction |
| Age | 0.02 | ||||||
| < 60 years | 314 | 1.0 | 120 | 1.01 (0.80, 1.26) | 218 | 0.86 (0.71, 1.03) | |
| ≥ 60 years | 611 | 1.0 | 611 | 1.05 (0.93, 1.18) | 1741 | 1.06 (0.96, 1.17) | |
| Hypertension | 0.56 | ||||||
| No | 355 | 1.0 | 222 | 1.01 (0.85, 1.21) | 582 | 1.00 (0.86, 1.15) | |
| Yes | 570 | 1.0 | 509 | 1.04 (0.92, 1.19) | 1377 | 1.04 (0.93, 1.16) | |
| Diabetes | 0.02 | ||||||
| No | 757 | 1.0 | 566 | 0.99 (0.88, 1.11) | 1618 | 1.02 (0.92, 1.12) | |
| Yes | 168 | 1.0 | 165 | 1.23 (0.97, 1.57) | 341 | 1.05 (0.85, 1.31) | |
| Smoking | 0.14 | ||||||
| Never | 320 | 1.0 | 289 | 1.11 (0.93, 1.31) | 804 | 1.05 (0.91, 1.21) | |
| Former | 314 | 1.0 | 301 | 1.03 (0.87, 1.21) | 877 | 1.06 (0.92, 1.23) | |
| Current | 291 | 1.0 | 141 | 1.01 (0.81, 1.26) | 278 | 0.88 (0.73, 1.06) | |
| aHEI | 0.42 | ||||||
| < 25th Percentile | 228 | 1.0 | 173 | 1.05 (0.85, 1.30) | 376 | 0.95 (0.80, 1.15) | |
| ≥ 25th Percentile | 697 | 1.0 | 558 | 1.02 (0.91, 1.15) | 1583 | 1.03 (0.93, 1.13) | |
| Folate intake | 0.71 | ||||||
| < 25th Percentile | 387 | 1.0 | 113 | 0.97 (0.79, 1.20) | 252 | 0.95 (0.79, 1.14) | |
| ≥ 25th Percentile | 538 | 1.0 | 598 | 1.07 (0.95, 1.21) | 1707 | 1.05 (0.94, 1.17) | |
| Fruit & vegetable intake | 0.30 | ||||||
| < 3 servings/day | 343 | 1.0 | 140 | 1.04 (0.92, 1.17) | 280 | 1.06 (0.96, 1.17) | |
| ≥ 3 servings/day | 583 | 1.0 | 591 | 1.05 (0.84, 1.31) | 1679 | 0.89 (0.74, 1.07) | |
| Strokes occurring | 0.18 | ||||||
| On/before 1994 | 531 | 1.0 | 231 | 1.02 (0.86, 1.20) | 423 | 0.95 (0.83, 1.09) | |
| After 1994 | 394 | 1.0 | 500 | 1.04 (0.91, 1.20) | 1536 | 1.04 (0.93, 1.17) | |
Cases=number of stroke events
aHEI = Alternative Healthy Eating Index
Models are adjusted for age, follow-up cycle, total calories, smoking, BMI, parental history of heart disease, alcohol intake, physical activity, aspirin and post, menopausal therapy use, Alternate Healthy Eating Index, history of hypertension, hypercholesterolemia and diabetes.