TABLE 5.
Multivariable Association Between Multivitamin Use and Total Stroke Mortality, Stratified by Key Risk Factors
| Multivitamin User
|
|||||||
|---|---|---|---|---|---|---|---|
| Risk Factors | Cases | Nonuser | Cases | Past User | Cases | Current User | P-interaction |
| Age | 0.04 | ||||||
| < 60 years | 77 | 1.0 | 19 | 0.99 (0.58, 1.72) | 37 | 0.74 (0.49, 1.12) | |
| ≥ 60 years | 118 | 1.0 | 139 | 1.19 (0.91, 1.54) | 368 | 1.12 (0.89, 1.41) | |
| Hypertension | 0.66 | ||||||
| No | 83 | 1.0 | 50 | 1.19 (0.81, 1.75) | 114 | 0.95 (0.69, 1.31) | |
| Yes | 112 | 1.0 | 108 | 1.17 (0.88, 1.57) | 291 | 1.16 (0.91, 1.49) | |
| Diabetes | 0.31 | ||||||
| No | 165 | 1.0 | 119 | 1.05 (0.82, 1.36) | 335 | 1.05 (0.85, 1.30) | |
| Yes | 30 | 1.0 | 39 | 1.67 (0.95, 2.91) | 70 | 1.15 (0.70, 1.90) | |
| Smoking | 0.71 | ||||||
| Never | 64 | 1.0 | 57 | 1.08 (0.73, 1.59) | 166 | 1.05 (0.75, 1.46) | |
| Former | 67 | 1.0 | 73 | 1.12 (0.78, 1.60) | 181 | 1.01 (0.74, 1.38) | |
| Current | 64 | 1.0 | 28 | 1.24 (0.75, 2.05) | 58 | 0.99 (0.67, 1.48) | |
| aHEI | 0.87 | ||||||
| < 25th Percentile | 41 | 1.0 | 36 | 1.12 (0.68, 1.83) | 76 | 1.06 (0.69, 1.63) | |
| ≥ 25th Percentile | 154 | 1.0 | 122 | 1.06 (0.82, 1.37) | 329 | 0.97 (0.78, 1.21) | |
| Folate intake | |||||||
| < 25th Percentile | 77 | 1.0 | 27 | 1.12 (0.69, 1.84) | 53 | 1.15 (0.77, 1.73) | 0.59 |
| ≥ 25th Percentile | 118 | 1.0 | 131 | 1.15 (0.88, 1.51) | 352 | 1.02 (0.80, 1.29) | |
| Fruit & vegetable intake | 0.50 | ||||||
| < 3 servings/day | 74 | 1.0 | 33 | 1.13 (0.87, 1.48) | 58 | 1.11 (0.88, 1.39) | |
| ≥ 3 servings/day | 121 | 1.0 | 125 | 1.40 (0.88, 2.24) | 347 | 0.93 (0.63, 1.39) | |
| Strokes occurring | 0.06 | ||||||
| On/before 1994 | 115 | 1.0 | 33 | 0.90 (0.59, 1.35) | 71 | 0.87 (0.63, 1.18) | |
| After 1994 | 80 | 1.0 | 125 | 1.29 (0.96, 1.74) | 334 | 1.18 (0.90, 1.53) | |
Cases=number of stroke events
aHEI = Alternative Healthy Eating Index
Models are adjusted for age, follow-up cycle, total calories, smoking, BMI, parental history of heart disease, alcohol intake, physical activity, aspirin and post, menopausal therapy use, Alternate Healthy Eating Index, history of hypertension, hypercholesterolemia and diabetes.