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. 2017 Mar 29;14(9):1232–1240. doi: 10.1080/15476286.2017.1307484

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© 2017 IBM. Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — m⁶A mRNA pathway in vertebrates and Drosophila melanogaster. The m⁶A methyltransferase complex is composed of five factors. In Drosophila, the methyltransferase complex controls neural development and sex determination via its nuclear reader YT521-B. The precise functions or roles of Virilizer and its vertebrate homolog KIAA1429 remain to be identified. No demethlyase has been found so far in Drosophila.