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. 2017 Nov 22;12(11):e0187746. doi: 10.1371/journal.pone.0187746

Table 7. Histopathological findings in the 3 patients (patient ID 7, 11 and 16).

Patient ID Gross findings, spinal cord Histopathological findings, spinal cord epicentre Additional findings, spinal cord
7 Herniated intervertebral disk material with adhesion to the dura mater at the epicentre, discoloration of spinal cord neuroparenchyma with washy demarcation between grey and white matter. Severe grey-matter accentuated myelomalacia; moderate multifocal infiltration of phagocytic gitter cells and gliosis; moderate multifocal myelin sheath dilatation and occasional myelinophages in all surrounding white matter fascicles. Mild multifocal osseous metaplasia of dura mater, so called pachymeningitis ossificans.
11 Severe extensive atrophy with hourglass-shape of spinal cord. Severe pan-myelomalacia with complete loss of organotypic structure of the neuroparenchyma and diffuse gliosis. Mild multifocal calcification of dura mater.
16 Mild focal atrophy with hourglass-shape of spinal cord; adhesion between spinal dura mater and bony vertebral canal. Severe grey-matter accentuated myelomalacia; moderate multifocal infiltration of phagocytic gitter cells and gliosis; severe multifocal myelin sheath dilatation, multiple myelinophages, and axonal spheroids in all surrounding white matter fascicles. None.