Table 2. Median time to onset of clinical signs (in hours) and 95% confidence interval for each clinical sign across toxin dose groups, and median time to death (in hours) and range.
| Clinical sign |
Intravenous Toxin Dose Median clinical onset time in hours (Range) |
|||
|---|---|---|---|---|
| 25 MIPLD50/kg (n = 4) | 40 MIPLD50/kg (n = 4) | 60 MIPLD50/kg (n = 4) | 160 MIPLD50/kg (n = 4) | |
| Ptosis | 42 (40, 61) |
30 (19, 41) |
21.5 (17, 32) |
17.5 (17, 19) |
| Muscular Weakness | 51 (40, 62) |
39.5 (19, 41) |
30.5 (26, 36) |
18.5 (16, 20) |
| Respiratory Distress | 64.5 (62, 89) |
39.5 (36, 43) |
34.5 (35, 36) |
19 (18, 23) |
| Oral Discharge | -- (102, --) |
47 (34, --) |
36 (35, 41) |
-- (20, --) |
| Nasal Discharge | -- | -- | -- (33, --) |
-- (20, --) |
| Death* | -- | 47 (40, 105) |
36.5 (35, 43) |
23 (20, 24) |
-- Not calculable due to limited number of events (i.e. limited observations of clinical sign and/or death).
* Only median time to death and range was reported