Table 1. The number of protein families and their protein-ligand clusters at varying cutoffs for sequence (% identity) and chemical similarity as defined by the Tanimoto coeffficient (Tc) using the extended connectivity fingerprint (ECFP6).

# Unique Ligands	#Protein Families (Providing #Protein-Ligand Clusters)
	100%/1	90%/0.9	75%/0.75	60%/0.6
70,219 Allosteric Ligands	1048 (144,685)	923 (95,955)	858 (54,739)	759 (24,760)
9511 Competitive Ligands	860 (14,215)	757 (13,259)	681 (9157)	599 (5259)