Table 3.
Linear regression models showing relationships between white matter signal abnormalities, repetitive head impact exposure, and psychomotor/speed executive function in the former NFL players (N = 86)
| Model variables | b (SE) | 95% CI | P-value |
|---|---|---|---|
| Log-white matter signal abnormalities | |||
| Age | 0.01 (0.004) | 0.002, 0.02 | .021 |
| Supratentorial volume | 0.0004 (0.0003) | −0.0002, 0.001 | .17 |
| Modified FSRP | 0.01 (0.01) | −0.01, 0.03 | .30 |
| CHII | 0.01 (0.004) | 0.0002, 0.02 | .043 |
| Psychomotor speed/executive function | |||
| Age | 0.02 (0.01) | −0.01, 0.05 | .12 |
| Supratentorial volume | 0.003 (0.001) | 0.001, 0.005 | .001 |
| Modified FSRP | −0.06 (0.03) | −0.12, 0.01 | .08 |
| White matter signal abnormalities | −0.11 (0.04) | −0.19, −0.02 | .015 |
Abbreviations: CHII, cumulative head impact index; CI, confidence interval; FSRP, Framingham Stroke Risk Profile.
NOTE. The FSRP is a modified version and did not include left ventricular hypertrophy. Age, supratentorial volume, and the modified FSRP were entered in block 1 of the regression model, and the CHII and white matter signal abnormalities were in block 2 (of separate models). Supratentorial volume, CHII, and white matter signal abnormalities were divided by 1000 to facilitate model fit. Bolded text indicates statistical significance.