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. Author manuscript; available in PMC: 2017 Nov 22.
Published in final edited form as: Nat Med. 2017 Mar 27;23(5):631–637. doi: 10.1038/nm.4297

Figure 1.

Figure 1

Discovery of 12,13-diHOME, a cold-induced lipokine linked to BAT activation. (a) Volcano plot of 88 lipids, comparing the fold induction after cold challenge to the P value (paired Student’s t-test). The dashed line indicates a P value of 0.05. 12,13-diHOME is highlighted in red. n = 9 human subjects. (b) Individual plasma concentration of 12,13-diHOME before and after cold challenge. The P value for a paired Student’s t-test is shown. (c) Plasma 12,13-diHOME concentration plotted with BAT-standardized uptake value (SUV), as measured by a positron-emission tomography (PET) scan of radiolabeled fluorodeoxyglucose. r is the Spearman correlation coefficient between 12,13-diHOME and BAT activity. (d–i) Circulating 12, 13-diHOME concentration plotted against BMI (d), HOMA-IR (score) (e), circulating triglycerides (f), circulating ALAT (g), circulating HDL cholesterol (h) and LDL cholesterol (i). Throughout, r is the Spearman correlation coefficient between 12,13-diHOME and each parameter. Blue dots represent males; pink dots, females. n = 55 individuals (13M/42F). P value was calculated using algorithm AS 89.