Fig. 8.
Delayed preconditioning effect of DLDH inhibition by MICA. MICA was administered via intraperitoneal injection for 7 consecutive days (once per day) and tMCAO surgery was performed 4 weeks after the last MICA injection. (A) Representative TTC staining showing the infarction areas of control and MICA; (B) Quantification of infarction volume (*p<0.05, mean ± SEM, n=5 for each group); (C) Nuclear content of Nrf2 assessed by gel shift analysis; (D) Comparison of NQO1 expression between control and MICA groups; (E) Densitometric quantification of NQO1 expression (normalized against the actin bands’ intensities) derived from D.