Table 1.

Top Upstream Regulators and Molecular and Cellular Functions of Gene Expression Changes in GSH-Deficient Lenses.

LEGSKO Epithelia	BSO-Treated LEGSKO Epithelia	LEGSKO Fiber Cells	BSO-Treated LEGSKO Fiber Cells
Upstream Regulators (p-value)
HSF4(5.32E-09)	HSF4(2.84E-10)	STIM1(4.23E-05)	HSF4(1.98E-08)
MAF(2.76E-06)	MAF(1.52E-07)	FGF1(5.56E-05)	MAF(2.31E-07)
GLUL(3.47E-06)	ANGPT2(7.22E-04)	NRF2(1.14E-04)	MAP2K1/2(1.67E-06)
MKNK1(3.89E-05)	ORC4(9.44E-04)	SOD1(2.79E-04)	GNA12(1.67E-06)
BDNF(2.84E-04)	ORC3(9.44E-04)	SQSTM1(3.60E-04)	APP(1.78E-06)
Molecular and Cellular Functions (p-value range)
Amino Acid Metabolism (1.82E-02 – 9.84E-06)	Cell Morphology (4.35E-02 – 7.47E-04)	Carbohydrate Metabolism (1.60E-02 – 2.42E-06)	Post-Translational Modification (4.93E-09 - 4.93E-09)
Post-Translational Modification (5.50E-03 – 9.84E-06)	Cellular Assembly and Organization (4.35E-02 – 8.47E-04)	Small Molecule Biochemistry (4.71E-02 – 2.42E-06)	Protein Degradation (4.93E-09 - 4.93E-09)
Small Molecule Biochemistry (4.67E-02 – 9.84E-06)	Cellular Compromise (3.99E-02 – 8.47E-04)	Vitamin and Mineral Metabolism (4.60E-03 – 2.42E-06)	Free Radical Scavenging (7.75E-03 – 9.15E-07)
Cellular Assembly and Organization (3.96E-02 – 5.50E-04)	Cellular Development (4.49E-02 – 8.47E-04)	Drug Metabolism (9.19E-03 – 4.28E-06)	DNA Replication, Recombination, and Repair (7.75E-03 – 3.79E-06)
Cellular Function and Maintenance (4.14E-02 – 5.50E-04)	Cellular Function and Maintenance (4.49E-02 – 8.47E-04)	Protein Synthesis (9.19E-03 – 4.28E-06)	Cell Morphology (1.03E-02 – 5.15E-06)