Table 2. Five-year cumulative incidence of local failure for the entire cohort and by patient, tumor, and treatment characteristics.
| Characteristic | Local failure (%) | Hazard ratio (95% CI) | P |
|---|---|---|---|
| All patients | 7.3 | - | - |
| Sex | |||
| Male | 6.7 | 1.0 | - |
| Female | 7.3 | 1.29 (0.81-2.06) | .28 |
| Age (y) | |||
| <18 | 6.7 | 1.0 | - |
| ≥18 | 11.9 | 1.97 (1.09-3.54) | .02* |
| Tumor site | |||
| Extremity | 5.4 | 1.0 | - |
| Pelvis | 13.2 | 2.47 (1.38-4.40) | <.01* |
| Axial non-spine | 5.3 | 0.95 (0.43-2.12) | .90 |
| Extraskeletal | 9.1 | 1.82 (0.94-3.54) | .08 |
| Spine | 3.6 | 0.60 (0.14-2.53) | .49 |
| Maximum tumor size (cm) | |||
| <8 | 8.3 | 1.0 | - |
| ≥8 | 7.9 | 0.92 (0.45-1.88) | .83 |
| Local treatment modality | |||
| Surgery | 3.9 | 1.0 | - |
| Radiation | 15.3 | 4.12 (2.39-7.12) | <.01* |
| Surgery + radiation | 6.6 | 1.69 (0.87-3.31) | .12 |
| Study | |||
| INT-0091 | 6.2 | 1.0 | - |
| INT-0154 | 8.0 | 1.38 (0.67-2.84) | .38 |
| AEWS0031 | 7.1 | 1.18 (0.58-2.39) | .66 |
Abbreviation: CI = confidence interval.
*
Statistically significant.