Table 2.

Comparison of cartilage T2 values (95% confidence intervals) between case (n=142) and control (n=426) cohorts. Differences were assessed using linear regression adjusting for age, BMI, gender, KL-scores, race and PASE in the main analysis and adjusting for BMI, gender, race and PASE in the sensitivity analysis by KL-score. Significant P-values (p < 0.05) are highlighted in bold.

Parameter	Non-injured (n = 426)	Injured (n = 142)	Adjusted P-value	Non-injured KL 0&1 (n = 246)	Injured KL0&1 (n = 76)	Adjusted P-value	Non-injured KL 2 (n= 180)	Injured KL2 (n= 66)	Adjusted P-value
	predicted mean values [95% CI] (ms)			predicted mean values [95% CI] (ms)			predicted mean values [95% CI] (ms)
Cartilage T2
Global knee T2	32.73 [32.54, 32.93]	33.29 [32.96, 33.63]	0.005	32.48 [32.23, 32.73]	33.25 [32.80, 33.70]	0.004	33.07 [32.77, 33.37]	33.40 [32.90, 33.90]	0.256
LF T2	35.57 [35.32, 35.81]	36.05 [35.62, 36.48]	0.058	35.16 [34.86, 35.46]	35.69 [35.14, 36.24]	0.098	36.09 [35.67, 36.50]	36.56 [35.86, 37.25]	0.257
LT T2	28.10 [27.82, 28.39]	29.11 [28.62, 29.61]	0.001	28.09 [27.72, 28.47]	29.48 [28.81, 30.14]	<0.001	28.11 [27.66, 28.56]	28.70 [27.95, 29.45]	0.188
MF T2	38.95 [38.69, 39.21]	39.07 [38.61, 39.53]	0.654	38.38 [38.04, 38.72]	38.98 [38.36, 39.60]	0.096	39.70 [39.30, 40.10]	39.27 [38.59, 39.94]	0.281
MT T2	29.70 [29.43, 29.98]	30.40 [29.92, 30.88]	0.014	29.45 [29.09, 29.80]	30.39 [29.76, 31.02]	0.011	30.04 [29.62, 30.46]	30.43 [29.70, 31.17]	0.365
PAT T2	31.57 [31.27, 31.86]	32.13 [31.61, 32.65]	0.065	31.50 [31.13, 31.86]	32.29 [31.64, 32.94]	0.038	31.68 [31.17, 32.18]	31.90 [31.03, 32.78]	0.661
Deep layer T2
Global knee deep layer T2	30.24 [29.92, 30.56]	31.19 [30.64, 31.75]	0.004	29.85 [29.55, 30.16]	30.89 [30.34, 31.44]	0.001	30.74 [30.12, 31.37]	31.62 [30.59, 32.66]	0.153
LF deep layer T2	33.27 [32.90, 33.64]	33.93 [33.28, 34.57]	0.087	32.72 [32.37, 33.06]	33.10 [32.48, 33.73]	0.290	34.00 [33.26, 34.75]	35.00 [33.76, 36.25]	0.176
LT deep layer T2	24.87 [24.46, 25.28]	26.37 [25.65, 27.08]	<0.001	24.78 [24.29, 25.27]	26.62 [25.74, 27.50]	<0.001	24.98 [24.29, 25.68]	26.08 [24.90, 27.26]	0.118
MF deep layer T2	36.79 [36.39, 37.19]	37.47 [36.77, 38.16]	0.098	36.12 [35.73, 36.51]	36.93 [36.24, 37.63]	0.045	37.68 [36.91, 38.46]	38.23 [36.91, 39.55]	0.486
MT deep layer T2	27.52 [27.10, 27.94]	28.66 [27.91, 29.40]	0.009	27.32 [26.78, 27.85]	28.47 [27.53, 29.42]	0.037	27.78 [27.09, 28.47]	28.96 [27.75, 30.16]	0.098
PAT deep layer T2	29.02 [28.61, 29.43]	30.11 [29.38, 30.83]	0.011	28.57 [28.18, 28.96]	29.84 [29.15, 30.54]	0.002	29.70 [28.84, 30.55]	30.50 [29.05, 31.95]	0.349
Superficial layer T2
Global knee superficial T2	35.69 [35.33, 36.05]	36.54 [35.91, 37.16]	0.021	35.69 [35.33, 36.05]	36.54 [35.91, 37.16]	0.011	36.20 [35.50, 36.90]	37.01 [35.84, 38.17]	0.248
LF superficial T2	38.06 [37.65, 38.48]	39.08 [38.35, 39.80]	0.018	37.55 [37.13, 37.96]	38.48 [37.73, 39.23]	0.034	38.73 [37.93, 39.53]	39.91 [38.57, 41.25]	0.141
LT superficial T2	31.77 [31.35, 32.19]	32.98 [32.25, 33.72]	0.005	31.66 [31.22, 32.11]	32.93 [32.13, 33.73]	0.007	31.91 [31.11, 32.70]	33.07 [31.73, 34.40]	0.144
MF superficial T2	41.41 [40.99, 41.84]	41.85 [41.10, 42.60]	0.326	40.65 [40.20, 41.09]	41.53 [40.73, 42.33]	0.060	42.42 [41.62, 43.23]	42.38 [41.00, 43.76]	0.959
MT superficial T2	32.79 [32.35, 33.23]	33.52 [32.74, 34.30]	0.109	32.33 [31.81, 32.85]	33.03 [32.10, 33.95]	0.201	33.38 [32.61, 34.15]	34.24 [32.90, 35.59]	0.275
PAT superficial T2	34.74 [34.22, 35.25]	35.57 [34.66, 36.47]	0.118	34.53 [34.02, 35.04]	35.45 [34.54, 36.36]	0.085	35.05 [34.01, 36.10]	35.74 [33.96, 37.52]	0.511