Table 4.

Comparison of WORMS Grading for meniscal and cartilage lesions and bone marrow edema pattern (95% confidence intervals) between case (n=142) and control (N=426) cohorts. Differences were assessed using linear regression models adjusting for age, BMI, gender, KL-scores, race and PASE in the main analysis and adjusting for BMI, gender, race and PASE in the sensitivity analysis by KL-score. None of the P-values was significant in the main analysis (p > 0.05). Significant P-Values in the sensitivity analysis by KL score are highlighted in bold

WORMS scores	Non-Injured (n = 426)	Injured (n = 142)	Adjusted P-value	Non-injured KL 0&1 (n = 246)	Injured KL0&1 (n = 76)	Adjusted P-value	Non-injured KL 2 (n= 180)	Injured KL2 (n= 66)	Adjusted P-value
	predicted mean [95% CI]			predicted mean [95% CI]			predicted mean [95% CI]
Cartilage lesions
Sum Score	4.23 [3.92, 4.53]	4.12 [3.58, 4.65]	0.732	2.96 [2.61, 3.31]	2.92 [2.29, 3.55]	0.913	5.87 [5.32, 6.43]	5.71 [4.79, 6.63]	0.768
Max Score	2.58 [2.43, 2.74]	2.43 [2.16, 2.70]	0.330	1.94 [1.75, 2.13]	1.86 [1.52, 2.21]	0.717	3.42 [3.16, 3.68]	3.18 [2.75, 3.61]	0.357
LF	0.37 [0.28, 0.45]	0.45 [0.30, 0.60]	0.333	0.19 [0.09, 0.28]	0.40 [0.23, 0.58]	0.033	0.60 [0.45, 0.76]	0.54 [0.29, 0.80]	0.700
LT	0.65 [0.54, 0.76]	0.75 [0.56, 0.93]	0.393	0.49 [0.37, 0.61]	0.70 [0.48, 0.93]	0.101	0.86 [0.67, 1.05]	0.83 [0.51, 1.15]	0.881
MF	0.76 [0.65, 0.87]	0.64 [0.45, 0.83]	0.296	0.51 [0.38, 0.63]	0.37 [0.15, 0.60]	0.305	1.09 [0.89, 1.29]	0.99 [0.66, 1.32]	0.602
MT	0.23 [0.15, 0.30]	0.35 [0.22, 0.48]	0.122	0.15 [0.07, 0.23]	0.12 [-0.02, 0.26]	0.776	0.33 [0.19, 0.48]	0.62 [0.38, 0.87]	0.048
PAT	2.22 [2.05, 2.38]	1.93 [1.64, 2.21]	0.085	1.63 [1.44, 1.82]	1.32 [0.97, 1.66]	0.120	2.98 [2.69, 3.27]	2.72 [2.24, 3.20]	0.362
Meniscus lesions
Sum Bilateral	1.62 [1.39, 1.85]	1.77 [1.37, 2.17]	0.536	1.26 [0.97, 1.54]	1.80 [1.28, 2.31]	0.072	0.91 [0.81, 1.01]	0.92 [0.75, 1.09]	0.926
Sum Medial	0.88 [0.74, 1.02]	0.93 [0.68, 1.17]	0.750	0.69 [0.53, 0.86]	0.78 [0.48, 1.07]	0.635	1.12 [0.87, 1.37]	1.14 [0.73, 1.55]	0.937
Sum Lateral	0.74 [0.58, 0.91]	0.84 [0.56, 1.13]	0.553	0.56 [0.36, 0.77]	1.02 [0.66, 1.38]	0.031	0.97 [0.69, 1.24]	0.68 [0.22, 1.14]	0.288
Max Bilateral	0.91 [0.81, 1.01]	0.92 [0.75, 1.09]	0.926	0.73 [0.61, 0.85]	0.87 [0.66, 1.09]	0.275	1.14 [0.97, 1.30]	1.01 [0.75, 1.29]	0.461
Max Medial	0.63 [0.55, 0.72]	0.66 [0.52, 0.81]	0.720	0.52 [0.42, 0.62]	0.52 [0.34, 0.70]	0.948	0.78 [0.64, 0.93]	0.85 [0.61, 1.09]	0.640
Max Lateral	0.45 [0.37, 0.54]	0.49 [0.35, 0.64]	0.629	0.36 [0.25, 0.46]	0.60 [0.42, 0.79]	0.024	0.57 [0.43, 0.71]	0.39 [0.16, 0.62]	0.180
Bone marrow edema pattern
Sum Score	1.29 [1.14, 1.44]	1.26 [1.00, 1.52]	0.848	0.88 [0.72, 1.05]	0.93 [0.64, 1.22]	0.791	1.83 [1.55, 2.11]	1.72 [1.25, 2.18]	0.692
Max Score	0.97 [0.88, 1.06]	0.84 [0.68, 0.99]	0.135	0.97 [0.88, 1.06]	0.84 [0.68, 0.99]	0.135	0.97 [0.88, 1.06]	0.84 [0.68, 0.99]	0.135
LF	0.08 [0.05, 0.12]	0.10 [0.03, 0.16]	0.734	0.04 [0.00, 0.08]	0.12 [0.05, 0.19]	0.050	0.15 [0.08, 0.21]	0.07 [-0.04, 0.18]	0.296
LT	0.14 [0.09, 0.18]	0.22 [0.14, 0.30]	0.083	0.06 [0.01, 0.10]	0.24 [0.15, 0.32]	0.000	0.24 [0.14, 0.33]	0.22 [0.06, 0.37]	0.858
MF	0.19 [0.14, 0.25]	0.15 [0.06, 0.23]	0.357	0.12 [0.07, 0.18]	0.08 [-0.02, 0.18]	0.463	0.29 [0.19, 0.38]	0.24 [0.07, 0.40]	0.600
MT	0.11 [0.07, 0.16]	0.17 [0.10, 0.25]	0.198	0.04 [0.00, 0.07]	0.07 [0.00, 0.14]	0.388	0.22 [0.13, 0.31]	0.30 [0.15, 0.45]	0.337
PAT	0.77 [0.68, 0.85]	0.63 [0.48, 0.78]	0.115	0.63 [0.53, 0.74]	0.42 [0.23, 0.61]	0.060	0.94 [0.80, 1.08]	0.88 [0.65, 1.12]	0.678
WORMS overall	8.96 [8.33, 9.58]	9.13 [8.04, 10.21]	0.794	6.14 [5.40, 6.88]	6.97 [5.65, 8.30]	0.283	12.63 [11.53, 13.73]	12.04 [10.22, 13.87]	0.590