TABLE 2.
Descriptions of 15 patients with PD-HGG
| Patient # |
Age at diagnosis (years) |
Site of disease |
Method of obtaining initial tissue sample |
Site of initial tissue sampling |
Initial histopathology |
Radiation therapy prior to repeat sampling Yes/No/Type |
Method of obtaining repeat tissue sample |
Site of repeat tissue sample |
Repeat histopathology |
Time from initial histologic diagnosis to MT/second HGG (years) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0.2 | Midbrain/Thalamus | Biopsy | Thalamus | Astrocytoma, NOS | Yes/Focal | STR | Midbrain, Thalamus | GB | 11.9 |
| 2 | 0.8 | Midbrain/Thalamus | Biopsy | Midbrain | Fibrillary astrocytoma | No | Biopsy | Thalamus | GB | 6.5 |
| 3 | 4.8 | Optic pathway/ Cerebellum | STR | Cerebellum | Pilocytic astrocytoma | Yes/Focal | Autopsy | Cerebellum | GB | 5.5 |
| 4 | 5.2 | Midbrain/Thalamus | Biopsy | Thalamus | Astrocytoma, NOS | Yes/Focal | Autopsy | Midbrain/brain stem | GB | 10.7 |
| 5 | 6.4 | Midbrain/Thalamus | Biopsy | Thalamus | Oligodendroglioma | Yes/CSI | Autopsy | Thalamus | Anaplastic oligodendroglioma | 1.3 |
| 6 | 7.7 | Midbrain/Thalamus | NTR | Thalamus | Glioma, NOS | Yes/Focal | PR | Left CP angle lesion | Glioma, High Grade | 4.7 |
| 7 | 8.8 | Midbrain/ Thalamus | Biopsy | Thalamus | Fibrillary astrocytoma | Yes/Focal | PR | Thalamus | GB | 1.3 |
| 8 | 12.3 | Hemispherical | GTR | Right parieto-occipital cortex | PXA | No | GTR | Right parietal lobe | Anaplastic PXA | 1.9 |
| 9 | 13.3 | Midbrain/Thalamus | STR | Thalamus | Pilocytic astrocytoma | Yes/Focal | Biopsy | Frontal lobe | Glioma, High Grade | 1.7 |
| 10 | 16.8 | Hemispherical | PR | Right frontal lobe | Oligoastrocytoma | Yes/Focal | GTR | Right frontal lobe | GB | 2 |
| 11 | 16.3 | Midbrain/Thalamus | GTR | Thalamus | Ganglioglioma | No | Biopsy | Thalamus | Astrocytoma, High Grade | 7.4 |
| 12 | 21 | Midbrain/Thalamus | Biopsy | Right midbrain | Pilocytic astrocytoma | Yes/Focal | Autopsy | Midbrain | GB | 9.3 |
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| Likely second HGG | ||||||||||
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| 13 | 2.9 | Midbrain/Thalamus | Biopsy | Right Thalamus | Fibrillary astrocytoma | Yes/Focal | PR | Right basal ganglia, temporal lobe | GB | 6.7 |
| 14 | 8.1 | Midbrain/Thalamus | Biopsy | Midbrain | Pilocytic astrocytoma | Yes/Focal | Biopsy | Right cerebellar hemisphere | GB | 22.9 |
| 15 | 21 | Midbrain/Thalamus | Biopsy | Midbrain | Astrocytoma, NOS | Yes/Focal | Biopsy | Right middle CP | Glioma, High Grade | 17.9 |
Abbreviations: PD-HGG, progressive disease with high-grade glioma at progression; CP, cerebellar peduncle ;GB, glioblastoma; GTR, gross-total resection; HGG, high-grade glioma; NOS, not otherwise specified; MT, malignant transformation; NTR, near-total resection; PR, partial resection; PXA, pleomorphic xanthoastrocytoma; STR, subtotal resection