Table 1.
Number of subject-reported adverse events by dosing cohorts, grouped by category
| Category | Neurological | Hearing | Visual | Gastrointestinal | Chills | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Dose (mg/kg) | Headache | Feeling abnormal | Fatigue | Dizziness | Hypoacusis | Tinnitus | Blurred vision | Nausea | Vomiting | Chills |
| 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 60 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 1 | 0 |
| 90 | 2 | 1 | 1 | 0 | 3 | 0 | 1 | 1 | 0 | 2 |
| 120 | 3 | 1 | 2 | 2 | 3 | 4 | 2 | 2 | 1 | 2 |
| 130 | 3 | 2 | 4 | 1 | 4 | 4 | 1 | 3 | 1 | 6 |
| 140 | 5 | 0 | 2 | 3 | 6 | 4 | 2 | 2 | 1 | 7 |
| 150 | 2 | 0 | 0 | 2 | 2 | 1 | 0 | 1 | 1 | 1 |
|
| ||||||||||
| Total | 16 | 4 | 9 | 8 | 19 | 15 | 6 | 10 | 5 | 18 |
Data are presented as number of self-reported adverse events (AE) in each dose category. Many subjects reported more than one AE