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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Clin Pharmacokinet. 2018 Feb;57(2):209–219. doi: 10.1007/s40262-017-0553-1

Table 2.

Pharmacokinetic system parameters based on 1-, 2-, and 3-compartment models

Model CL (L/h) Vc (L) Q1 (L/h) Vp1 (L) Q2 (L/h) Vp2 (L) AIC
1-Compartment 1.25 (0.51) 19.5 (5.57) NA NA NA NA 94.85
2-Compartment 1.16 (0.48) 11.1 (2.62) 0.64 (0.32) 7.70 (3.28) NA NA 91.03
3-Compartment 1.16 (0.49) 10.8 (2.74) 0.62 (0.29) 7.63 (3.29) 3.48(1.47) 0.32(0.06) 96.14

CL, clearance; Vc, volume of distribution of the central compartment; Q1, intercompartmental clearance between central and first peripheral compartment; Vp1, volume of distribution of the first peripheral compartment; Q2, intercompartmental clearance between central and second peripheral compartment; Vp2, volume of distribution of the second peripheral compartment; NA, not applicable. Values reported as mean (standard deviation).