Table 3.
Weight, absolute dosage, and exposure parameters of dosing cohorts
| Dose (mg/kg) | Weight (kg) | Dose (mg) | Cmax (mg/L) | C24 (mg/L) | Half-life (h) | AUC24 (h•mg/L) | AUCinf (h•mg/L) |
|---|---|---|---|---|---|---|---|
| 15 | 78.8 (14.3) | 1182 (214) | 112 (11.8) | 22.6 (5.64) | 12.1 (1.8) | 1184 (152) | 1714 (340) |
| 30 | 71.7 (9.6) | 2151 (288) | 235 (21.1) | 39.5 (11.8) | 12.1 (3.4) | 2205 (311) | 3386 (1033) |
| 60 | 66.8 (6.9) | 4009 (412) | 248 (25.4) | 39.8 (2.83) | 11.3 (2.1) | 2241 (174) | 3043 (377) |
| 90 | 77.4 (14.7) | 6966 (1322) | 541 (62.3) | 56.9 (25.4) | 8.9 (1.5) | 4626 (1044) | 5812 (1424) |
| 120 | 74.9 (12.2) | 8990 (1467) | 537 (70.7) | 49.7 (19.7) | 9.0 (2.1) | 3843 (723) | 4983 (1332) |
| 130 | 82.1 (9.5) | 10667 (1231) | 855 (90.1) | 97.2 (11.9) | 8.8 (2.3) | 7745 (1404) | 11273 (1658) |
| 140 | 77.9 (6.8) | 10899 (955) | 1271 (178) | 140 (19.3) | 9.7 (1.0) | 9870 (898) | 13520 (1621) |
| 150 | 64.2 (4.4) | 9630 (658) | 694 (62.9) | 81.4 (34.7) | 7.9 (3.7) | 6911 (571) | 8521 (226) |
Values reported as mean (standard deviation).