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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Leukemia. 2017 May 22;31(12):2686–2694. doi: 10.1038/leu.2017.152

Figure 4. Scl-Ab treatment increases osteoblasts in mice with established MM disease.

Figure 4

Static histomorphometry quantification of osteoblasts (a) and osteoclasts (b) in bone of mice treated with IgG or Scl-Ab; # p≤0.05 vs IgG-treated (saline) mice; *p≤0.05 vs saline-injected mice. Serum levels of P1NP (a) and CTX (b); # p≤0.05 vs IgG-treated (saline) mice; *p≤0.05 vs saline-injected mice. Saline/5TGM1-injected: n=9/9 IgG and n=10/7 Scl-Ab (c) Black dotted lines indicated bone surfaces, yellow arrows point at osteoblasts, and red arrows point at TRAP positive osteoclasts.