Table 1.
| a. Demographic and clinical data for probands with a history of psychosis and healthy controls | |||||
|---|---|---|---|---|---|
|
| |||||
| Healthy Controls |
Schizophrenia Probands |
Schizoaffective Probands |
Bipolar Probands |
||
|
| |||||
| n=391 | n=321 | n=200 | n=258 | Findings | |
| Age in Years Mean(SD) | 37.62(12.57) | 35.70(12.87) | 36.85(11.79) | 36.04(12.76) | F=1.61ns |
| Years of Education Mean (SD) a | 14.92(2.52) | 12.76(2.28) | 13.04(2.14) | 14.16(2.35) | F=58.96*** |
| WRAT-IV: Reading Mean(SD) b | 103.29(13.76) | 94.47(15.45) | 97.00(14.73) | 101.56(14.09) | F=25.41*** |
| Gender c | |||||
| Male | 45.0 % | 67.6 % | 40.5% | 36.4 % | χ2 = 68.95*** |
| Female | 55.0% | 32.4% | 59.5% | 63.6% | |
| Raced | |||||
| Caucasian | 62.7 % | 46.4% | 55.0 % | 75.2 % | |
| African-American | 28.1% | 44.9% | 40.0% | 19.4% | χ2 = 60.61*** |
| Other | 9.2% | 8.7% | 5.0% | 5.4% | |
|
| |||||
| Clinical Data | |||||
|
| |||||
| MADRS e | 8.22(7.92) | 14.79(10.32) | 10.09(9.08) | F=31.76*** | |
| PANSS Positive f | 16.69(5.72) | 17.97(5.26) | 12.78(4.63) | F=63.12*** | |
| PANSS Negative g | 16.50(5.82) | 16.04(5.15) | 11.82(3.94) | F=67.22*** | |
| YMRS Total h | 5.56(5.82) | 7.56 (6.68) | 5.87(6.80) | F= 6.24** | |
| b. Demographic data, history of psychosis, and psychosis spectrum personality traits for first degree relatives | |||||
|---|---|---|---|---|---|
|
| |||||
| Healthy Controls |
Relatives of Schizophrenia Probands |
Relatives of Schizoaffective Probands |
Relatives of Bipolar Probands |
||
|
| |||||
| n=391 | n=298 | n=193 | n=271 | Findings | |
| Age in Years Mean(SD) a | 37.62(12.57) | 44.10(15.12) | 41.69(16.17) | 40.70(16.04) | F=11.28*** |
| Years of Education Mean (SD) b | 14.92(2.52) | 14.22(2.42) | 14.09(2.93) | 14.58(2.71) | F= 6.09*** |
| WRAT-IV: Reading Mean(SD) c | 103.29(13.76) | 98.88(14.64) | 100.45(16.40) | 103.82(14.12) | F= 7.60*** |
| Gender d | |||||
| Male | 45.0% | 28.5% | 26. 9% | 34.7% | χ2 = 28.09*** |
| Female | 55.0% | 71.5% | 73.1% | 65.3% | |
| Race e | |||||
| Caucasian | 62.7% | 56.4% | 63. 3% | 81.2% | |
| African-American | 28.1% | 38.9% | 32.6% | 14.4% | χ2 = 55.77*** |
| Other | 9.2% | 4.7% | 4.1% | 4.4% | |
WRAT-IV: Wide Range Achievement Test: Fourth Edition
YMRS: Young Mania Rating Scale
PANSS: Positive and Negative Syndrome Scale
MADRS: Montgomery Asberg Depression Rating Scale
p < 0.05;
p < 0.01;
p < 0.001
Healthy Control > Schizophrenia, Schizoaffective, & Bipolar; Bipolar > Schizophrenia & Schizoaffective
Healthy Control > Schizophrenia and Schizoaffective; Bipolar > Schizophrenia and Schizoaffective
Males over-represented in Schizophrenia group
African-Americans over-represented in Schizophrenia group
Schizoaffective > Bipolar > Schizophrenia
Schizoaffective > Schizophrenia > Bipolar
Schizophrenia & Schizoaffective > Bipolar
Schizoaffective > Schizophrenia & Bipolar
Healthy Controls < Schizophrenia Relatives, Schizoaffective Relatives, & Bipolar Relatives; Schizophrenia Relatives > Bipolar Relatives
Healthy Control > Schizophrenia and Schizoaffective
Healthy Control > Schizophrenia; Bipolar > Schizophrenia
Females over-represented in Schizophrenia & Schizoaffective Relative groups
Caucasians over-represented in Bipolar Relatives