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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2017 May 22;49:75–82. doi: 10.1016/j.semcancer.2017.05.008

Figure 3. Hypoxia-induced AGE-RAGE-mediated signaling pathways.

Figure 3

Hypoxia induces AGE accumulation which further formed complex with RAGE and activates several downstream pathways including NF-Kb, Hif1α, ERK and AKT signaling. These pathways further contribute to cancer metastasis progression.