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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2017 May 22;49:75–82. doi: 10.1016/j.semcancer.2017.05.008

Figure 4. Hypoxia-driven AGE-RAGE-mediated carcinogenesis is induced by Hif1α.

Figure 4

Hypoxic microenvironment induces glycolysis and dicarbonyls accumulation. These dicarbonyls further trigger AGE generation. Once AGE interact with their receptors, RAGE, they activate Hif1α signaling pathways which further act as a transcription factor for synthesis of cell survival and metastasis related genes.