Table 1.

Estimates of probability-related parameters used to determine the cost-effectiveness of PGS for women older than 37 using IVF

Parameter	Base-case estimate	Minimum value	Maximum value	Sources
Probability that a cycle has at least one euploid blastocyst (PGS arm)	64.0%	36.4%	82.0%	[7, 11, 13]
Probability that a blastocyst called euploid by PGS is transferred	100.0%	–	–	Authors’ Assumption
Probability that a blastocyst called aneuploid by PGS is transferred	0.0%	–	–	Authors’ Assumption
Probability of live birth in a pregnancy that results from euploid blastocysts and is not miscarried	99.8%	99.0%	100%	[7, 13]
Probability that at least one blastocyst meets traditional morphological criteria for transfer (non-PGS arm)	66.0%	49.5%	94.5%	[7, 14]
Probability that only one blastocyst is transferred in a transferred cycle (non-PGS arm)	11.4%	8.6%	14.3%	[7, 13]
Probability that a blastocyst selected for transfer by traditional morphological criteria is aneuploid (non-PGS arm)	30.6%	19.0%	55.2%	[12, 15]
Adjusted odds ratio of clinical pregnancy in a PGS guided cycle relative to a non-PGS guided cycle	1.18	1.05	3.86	[7, 13]
Probability of clinical pregnancy in a non-PGS guided cycle	42.5%	31.9%	49.5%	[7, 13]
Adjusted odds ratio of miscarriage (per pregnancy) in a PGS guided cycle relative to a non-PGS guided cycle	0.55	0.32	0.70	[7, 13]
Probability of miscarriage in a pregnancy resulting from a non-PGS guided cycle	26.0%	19.6%	39.0%	[7, 13, 14, 16]
Probability of live birth in a pregnancy that results from a non-PGS guided cycle and is not miscarried	97.8%	97.3%	99.0%	[7]