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PCSK9 in neuronal apoptosis. Figure is based on [56]. In the brain, hypercholesterolemia causes the emergence of reactive forms of oxLDL which stimulate PSCK9 synthesis. Under the influence of PCSK9 an NF-κB is activated through the activation of proapoptotic Bax proteins and caspases 3 and 9. This pathway leads to neuronal apoptosis. BBB brain blood barrier, NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells
