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. 2017 Nov 22;8:1707. doi: 10.1038/s41467-017-01645-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — JQ1 prolongs survival, and prevents muscle and white fat wasting. a Body weight chart of control, vehicle, (−)-JQ1, and (+)-JQ1-treated C26-tumor-bearing mice. Day 0: tumor implantation. Day 1: JQ1 treatment started. Age-matched normal control mice were treated with vehicle (animals per group: n = 10). Data represent means ± SD. Statistical significance refers to (+)-JQ1-treated animals vs. vehicle and (−)-JQ1-treated animals. b Chart displaying food intake in the six animal groups described in a. Data represent means ± SD. Statistical significance refers to (+)-JQ1-treated animals vs. vehicle and (−)-JQ1-treated animals. c Survival rate of C26-tumor-bearing mice was measured in two animal groups: vehicle (veh) and (+)-JQ1 20 mg/kg/day. Treatment was started either at day 1 (gray line) or when the average weight loss was 10% (blue line) (animals per group: n = 7). d Epididymal adipose tissue was weighted at day of sacrifice (day 12) in the six animal groups (animals per group: n = 10). Data represent means ± SD. e–g TA, EDL, and soleus were weighted 12 days after C26 cell implantation (animals per group: n = 10). Data represent means ± SD. h TA muscle morphology of Ctrl and C26-tumor-bearing mice treated with vehicle and (+)-JQ1 (animals per group: n = 3). (+)-JQ1 was administered at the dose of 20 mg/kg/day. Scale bar: 100 μm. i Treadmill test was performed on control and C26-tumor-bearing mice treated with (−)-JQ1 and (+)-JQ1 (20 mg/kg/day) at days 7 and 14 (animals per group: n = 4). Data represent means ± SD. Statistical significance refers to (+)-JQ1-treated animals vs. vehicle and (−)-JQ1-treated animals. *p < 0.05; **p < 0.01; ***p < 0.001. “a” indicates statistical significance compared to control; “b” indicates statistical significance compared to C26 + vehicle; “c” indicates statistical significance compared to C26 + (−)-JQ1 20 mg/kg/day; “d” indicates statistical significance compared to C26 + (−)-JQ1 50 mg/kg/day. Statistical analysis was performed by using one-way ANOVA followed by Tukey’s post hoc test in a, b, d–g, and i log-rank (Mantel–Cox) test in c