Table 3.
Effects of cumulative doses of risperidone on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.
| Urodynamic parameters | EUS EMG parameters | |||||||||||
| Dose | BC (ml) | MV (ml) | RV (%) | PT | PP | CT (sec) | ET (sec) | HFO | Phase 1 | Phase 2 | Phase 3 | Burst |
| (mg/kg) | (mm Hg) | (mm Hg) | (mm Hg) | (%) | (%) | (%) | Amp. | |||||
| (%) | ||||||||||||
| Control | 0.35 | 0.27 | 21 | 2.4 | 11.5 | 18.5 | 3.6 | 1.6 | 100 | 100 | 100 | 100 |
| (±0.097) | (±0.072) | (±5.6) | (±0.62) | (±0.95) | (±1.43) | (±0.83) | (±0.19) | |||||
| 0.01 | 0.38 | 0.17 | 47** | 2.8 | 11.7 | 19.3 | 2.7 | 1.3 | 100 | 76 | 91 (±8.4) | 105 |
| (±0.080) | (±0.033) | (±9.2) | (±0.72) | (±1.0) | (±1.97) | (±0.49) | (±0.12) | (±11.5) | (±14.7) | (±3.4) | ||
| 0.1 | 0.38 | 0.10* | 70** | 3.4 | 11.7 | 19.4 | 1.5** | 1.0* | 84 | 50* | 78* | 80 |
| (±0.055) | (±0.019) | (±7.8) | (±0.44) | (±0.82) | (±1.94) | (±0.34) | (±0.22) | (±11.7) | (±12.3) | (±10.1) | (±19.6) | |
| 1 | 0.40 | 0.12** | 67** | 5.0* | 12.4 | 18.6 | 1.4** | 0.9** | 74 | 47* | 68** | 76 |
| (±0.060) | (±0.016) | (±5.8) | (±1.02) | (±1.16) | (±2.6) | (±0.35) | (±0.18) | (±13.2) | (±12.7) | (±8.0) | (±14.0) | |
| 10 | 0.54 | 0.19 | 60** | 5.8** | 13.7** | 17.2 | 2.2* | 1.1* | 81 | 71 (±22) | 73** | 84 |
| (±0.080) | (±0.036) | (±7.7) | (±1.02) | (±1.34) | (±0.96) | (±0.46) | (±0.22) | (±15.2) | (±9.0) | (±14.6) | ||
| * | ||||||||||||
* p < 0.05; ** p < 0.01