Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 22;7:16005. doi: 10.1038/s41598-017-16228-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Dissociation of vasomotor and metabolic response to levodopa in the unilateral 6-OHDA rat dyskinesia model. (a) Voxel-wise searches over the whole brain volume revealed a distinct region in which local vasomotor (CBF) and metabolic (CMR) changes were significantly dissociated in response to levodopa. This cluster (red), comprised of 49 contiguous voxels (1 voxel = 0.8 × 0.8 × 0.8 mm) located at the border of the striatum and the ventral globus pallidus (GP) of the dopaminergically denervated right (R) cerebral hemisphere, was significant at a voxel-level threshold of p < 0.001 corrected for extent at p < 0.05 (see text). (b) Box-and-whisker plots of CBF and CMR values in this region. Left: Significant CBF–CMR dissociation was seen in the lesioned hemisphere (F_(1,8) = 10.85, p = 0.01, tracer × condition interaction effect; RMANOVA) with increased CBF (p < 0.01; post-hoc test) and no change in CMR (p = 0.70) in the OFF vs. ON condition. Right: Analogous changes were not seen in the contralateral non-lesioned hemisphere (p = 0.53). [Horizontal bars below box plots represent paired Student’s t-tests.] (c) Levodopa-mediated dissociation responses in this region were measured in the dopaminergically denervated and non-denervated hemispheres (see Methods). Dissociation responses were significantly greater on the 6-OHDA lesioned side relative to its non-lesionsed counterpart (p < 0.04; paired Student’s t-test).