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. 2017 Nov 22;7:16005. doi: 10.1038/s41598-017-16228-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Levodopa-mediated changes in [¹¹C]-AIB uptake in the unilateral 6-OHDA rat dyskinesia model. (a) Voxel-wise searches over the whole brain volume revealed a distinct area of increased [¹¹C]-AIB uptake across the blood-brain-barrier (BBB) in responses to levodopa. This cluster (red) was comprised of 159 contiguous voxels (1 voxel = 0.8 × 0.8 × 0.8 mm) located in the globus pallidus (GP) of the dopaminergically denervated right (R) cerebral hemisphere. (b) Box-and-whisker plots of [¹¹C]-AIB uptake values for this cluster measured in the PRE, OFF, and ON levodopa conditions (see text). There was a significant condition (ON/OFF) × hemisphere (lesioned/non-lesioned) interaction in this region (F_(1,9) = 7.92, p < 0.03; RMANOVA), with a significant effect on the denervated side (p < 0.02; post-hoc test). Analogous changes were not seen in the contralateral non-lesioned hemisphere (p = 0.99). [Horizontal bar below box plot represents paired Student’s t-test].