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. 2017 Nov 22;7:16037. doi: 10.1038/s41598-017-15464-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A synthetic gene network integrated in human kidney cells. The bidirectional promoter transcribes the zsGreen-LacI and dsRed transcripts. The gene network includes two architectures: a negative-feedback network and a network with no feedback. The zsGreen-LacI transcripts are inhibited by LacI, forming a network with negative autoregulation. The dsRed transcripts are not regulated, forming a network with no feedback.