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. 2017 Nov 22;7:16037. doi: 10.1038/s41598-017-15464-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inference of the network topology by using single-cell data. (a)–(d) The noise $η$ (blue), feedback-free noise $η - η_{f}$ (green), and feedback coefficient $η_{f}$ (red) for the zsGreen and dsRed proteins under different IPTG concentrations. The error bars are standard deviations given by bootstrap. (a) zsGreen in the high Dox case. (b) reRed in the high Dox case. (c) zsGreen in the low Dox case. (d) reRed in the low Dox case.