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. 2017 Nov 22;8:1700. doi: 10.1038/s41467-017-01711-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Mafb ^−/− mice develop autoimmune disease. a ELISA analysis showed the ANA levels in serum from 6 to 12-month-old transplanted mice (WT, n = 13; Mafb ^−/−, n = 9). b The production of anti-ds-DNA was observed in serum (n = 16 for each genotype). c The ANA level of Mafb ^f/f::LysM-Cre and Mafb ^f/f were analyzed by ELISA (Mafb ^f/f, n = 9; Mafb ^f/f::LysM-Cre, n = 10). d Serum anti-ds-DNA was analyzed by ELISA (Mafb ^f/f, n = 7; Mafb ^f/f::LysM-Cre, n = 9). a–d The results of duplicate independent experiments were pooled. e Kidneys were stained with PAS and HE staining. Glomerulonephritis was scored from 0 to 3 in a blinded test (WT, n = 16; Mafb ^−/−, n = 15). The data were analyzed with the Brunner–Munzel test. f The deposition of immune complexes in glomeruli was assayed for the immune complex (IgG + IgM + IgA). g Immune complex-positive glomeruli were quantified (WT, n = 5; Mafb ^−/−, n = 5). h Urinary protein was measured in WT and Mafb ^−/− 12-month-old transplanted mice (WT, n = 17; Mafb ^−/−, n = 12). The data are presented as the mean ± s.e.m. *p < 0.05 (Welch’s t-test). The results of two independent experiments were pooled