Table 1.
Effect of pyridoxamine on global conventional echocardiographic parameters.
| Parameter | Sham | MI | MI + PM |
|---|---|---|---|
| HR (bpm) | 357 [365; 346] | 365 [365; 342] | 358 [388; 340] |
| EF (%) | 67 [68; 67] | 48 [60; 39]* | 46 [47; 45]* |
| AWT (mm) | 1.52 [1.55; 1.47] | 0.98 [0.98; 0.93]* | 1.02 [1.06; 0.98]* |
| PWT (mm) | 1.69 [1.74; 1.61] | 1.33 [1.42; 1.25]* | 1.51 [1.77; 1.32] |
| LVEDD (mm) | 6.5 [6.6; 6.4] | 8.9 [9.1; 7.8]* | 7.9 [8.7; 7.4]* |
| LVESD (mm) | 4.2 [4.2; 4.1] | 6.2 [6.5; 6.0]* | 6.4 [6.8; 6.0]* |
| EDV (µL) | 288 [311; 269] | 570 [599; 439]* | 451 [537; 384]* |
| ESV (µL) | 94 [100; 91] | 229 [266; 216]* | 248 [289; 212]* |
| SI | 0.25 [0.26; 0.25] | 0.42 [0.43; 0.31]* | 0.36 [0.42; 0.30]* |
HR, heart rate; EF, left ventricular ejection fraction; AWT, anterior wall thickness; PWT, posterior wall thickness; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; EDV, end diastolic volume; ESV, end systolic volume; SI, sphericity index;. Data are shown as median [75th percentile, 25th percentile] in Sham (N = 5), MI (N = 5) and MI + PM (N = 6). *Denotes p < 0.05 vs Sham.